In prostate cancer cells, the RIG-I-MAVS signaling pathway can be activated by transfecting with inactivated Sendai virus to induce the secretion of IFNs and induction of several ISGs, which result in cancer cell-selective apoptosis (Kawaguchi et al., 2009; Kato et al., 2010; Matsushima-Miyagi et al., 2012; Liu et al., 2016b). The gene discussed is RIGI; the disease is prostate cancer.