For example, besides recognizing exogenous viral RNAs, RIG-I closely associates with various endogenous RNAs, such as microRNAs, snRNAs, and endogenous retroviruses (ERVs) in certain situations, which participates in many important cellular activities, such as the therapy resistance and expansion of cancer cells, and the activation of T cell-independent B cells (Karlsen et al., 2013; Boelens et al., 2014; Zeng et al., 2014; Zhao et al., 2015; Ranoa et al., 2016). The gene discussed is RIGI; the disease is cancer.