Characterizing their iPSC-based FTD model comprising two patient lines, two control lines and also a MAPT knockout line, Silva et al. discovered elevated levels of LC3-II, p62, LAMP1, LAMP-2A, ATG12-5 and also an accumulation of ubiquitinated proteins in 35-day-old cortical neuronal cultures derived from MAPTA152T iPSCs [92]. This evidence concerns the gene MAPT and frontotemporal dementia.