As up to 85% of children with NF1 have abnormal signal on their MRI scans (FASIs), and the thalamus is a common location to see these changes [10], it is important to discuss cases with an experienced neuroradiologist to ensure that FASI don’t have any atypical features that may suggest the presence of a low grade glioma. Here, NF1 is linked to central nervous system cancer.