In in vitro and in vivo experimental models of PD and PACAP displayed not only antiapoptotic but also antiautophagic properties since they decreased autophagic vacuole formation and lipidated LC3 levels and the expression of the autophagosomal cargo protein p62 [42], which serves as a link between LC3 and ubiquitinated substrates. This evidence concerns the gene ADCYAP1 and Parkinson disease.