In cultured neonatal rat ventricular cardiomyocytes it has been reported that Ang-II-stimulated cardiomyocyte hypertrophy upregulated the expression of LC3-II as well as the number of autophagic vacuoles and the inhibition of Ang-II-induced effects on autophagy has been suggested to protect against pathological myocardial hypertrophy [96]. This evidence concerns the gene AGT and cardiac hypertrophy.