SOD1 and injury: Accordingly, in a rat model of COC-induced heart injury, Moritz and coworkers [122] had shown that COC long-term administration caused a significant decrease in SOD activity; a biphasic trend in SOD concentration in rat spleen was observed after chronic COC administration in vivo [131] since that, after an early peak, SOD was significantly depleted 24 hours after COC treatment.