In a search of a tumor-suppressive role of miRNAs in medulloblastoma, miR-128a, which is downregulated in this type of tumor, was found to inhibit cancer cell growth by promoting senescence, through increased ROS production, upregulation of p16 protein level, and increased number of SA-β-Gal positive cells [116]. The gene discussed is CDKN2A; the disease is neoplasm.