Molecular alterations such as microsatellite instability (MSI), abnormal mismatch repair protein (MMR) proteins MLH1, PMS2, MSH2, MSH6, and loss of heterozygosity (LOH) of 9p21, 3p14 have been found to characterize premalignant oral lesions [106–108, 110, 111]; while perturbation of p53, EGFR/STAT, COX-2, NF-κB, VEGF, TGF-β/Ras pathways have been found in oral squamous cell carcinoma [112–114]. Here, EGFR is linked to oral cavity squamous cell carcinoma.