MECP2 and Rett syndrome: Based on the previous data demonstrating a clear phenotype in Mecp2-308 females [30], the present study was carried out in symptomatic heterozygous female mice, the genetic and hormonal milieus that, from a translational point of view, is closer to the ones of RTT patients; indeed, among RTT patients, MECP2 mutations are missense and truncated mutations, not deletions [2, 11].