The BIRC5 (survivin) gene and its spliced isoforms have been shown to be associated with prostate cancer cell proliferation and aggressive phenotypes26; and tumour-associated splice variants of MACF1, ITGB3, TLE3, SHC1, ETS1 and BCAS1 have been reported in lung, prostate, breast cancer and glioblastoma27–32. This evidence concerns the gene TLE3 and Familial prostate cancer.