In the present study, the finding that NOD1 is involved in the regulation of NLRC3 homologues, nutrient metabolism as well as the CD44a-mediated PI3K/Akt/mTOR pathway is very intriguing, which suggest the multiple functions of NOD1 in different field of biology including infectious disease, metabology, oncology, developmental biology, and not confined to the immunology. The gene discussed is NLRC3; the disease is infectious disease.