More interestingly, the values we calculated for Km and Vmax in native environments were comparable between human GCS in NCI/ADR-RES cancer cells in culture (2.3 μM and 343 fmol/μg-2 h incubations) (Fig. 2b) and mouse GCS in liver following systemic administration (1.8 μM and 148 fmol/μg-3 h incubation). The gene discussed is UGCG; the disease is cancer.