We recently demonstrated that the increase of cellular NAD+ levels by NQO1 enzymatic action using the substrate β-Lapachone (β-Lap), a quinone-containing natural compound (3,4-dihydro-2,2-dimethyl-2H naphtho [1,2-b] pyran-5–6-dione), suppresses cisplatin-induced acute kidney injury and hearing impairment by downregulating oxidative stress and inflammatory responses7, 8. The gene discussed is NQO1; the disease is acute kidney injury.