TGFB1 and Hepatic fibrosis: Since TGF-β1 increased during liver fibrogenesis triggered by various causes, it’s tempting to speculate that TGF-β1-mediated upregulation of lincRNA-p21 may work as a specific downstream effector of TGF-β signaling in hepatocyte, and therefore represent a hitherto unknown paradigm in liver fibrosis.