ACSS2 and hypogonadism: In this study typical physical exam findings growth retardation, hypogonadism, thalassemic bone deformities, diabetes mellitus6–9 were included to identify the association between four genotype (SEA, -α3.7/–SEA, -α4.2/–SEA, αCSα/–SEA) and endocrine complications in children with α-thalassemia.