Furthermore, it has been recently discovered that maternal high-fat feeding during lactation in mice severely alters the projections of POMC and AgRP neurons to second-order neurons, resulting in increased obesity and impaired glucose homeostasis in the offspring (Vogt et al., 2014; for review, see Vogt and Brüning, 2013). The gene discussed is POMC; the disease is obesity due to melanocortin 4 receptor deficiency.