SARS-CoV infection is sensed by TLR3 and TLR4 (Totura et al. 2015), and SARS-CoV actively evadesdetection of its cytosolic RNA by MDA5 through the 2′ methyltransferase activity of the viralnsp16 protein (Menachery et al.2014). This evidence concerns the gene TLR4 and severe acute respiratory syndrome.