In our cohort of patients with cirrhosis and ACLF, HLA-DR expression on CD14+ myeloid cells strongly negatively correlated with established scores of liver disease severity Child-Pugh, MELD, CLIF-SOFA (figure 2C), NACSELD score (r=−0.53, p<0.001, n=98) and also SIRS score (r=−0.46, p<0.001, n=96). Here, CD14 is linked to systemic inflammatory response syndrome.