Feeding LDLR-null mice a chow diet supplemented with unsaturated (but not saturated) lysophosphatidylcholine (LysoPC) or lysophosphatidic acid (LPA) produced dyslipidemia and systemic inflammation (plasma SAA and IL-6 levels), and the extent and cellular characteristics of aortic atherosclerosis approached that seen on WD (14, 16, 21). Here, LDLR is linked to metabolic syndrome.