To our knowledge, this is the first report that IFN-β is induced in the enterocytes of the small intestine by WD, and this is the first report that small intestine IFN-β, CH25H, and 25-OHC levels are potently and favorably modulated by an oral apoA-I mimetic peptide and ezetimibe. The gene discussed is APOA1; the disease is Wilson disease.