When the unmatched groups were compared, ICU type (emergency center or surgical ICU), route of admission to the ICU, ICU policy, number of ICU beds, pre-existing organ dysfunction, SOFA score, JAAM DIC, primary infection site, microorganism, WBC, platelet counts, Hb, PT-INR, PRBC, surgical intervention, and other therapeutic interventions (rhsTM, AT III concentrate, protease inhibitors, IVIG, low-dose steroids, RRT, and non-renal RRT) differed significantly between the two groups. Here, SERPINC1 is linked to infection.