Given that we propose KAT2A and MYC as candidate driver TFs in PRAD which are overexpressed in tumours relative to normal prostate tissue, one might expect to see a more ‘normal-like’ compartment profile in tumours with low KAT2A or MYC expression relative to those with high KAT2A and MYC expression. Here, KAT2A is linked to prostate adenocarcinoma.