Remarkably, we noted that increased expression of A2AR was correlated with higher pathological grade (Fig. 1d, Grade I vs. II, P < 0.001, Grade I vs. Grade III, P < 0.001), larger tumor size (Fig. 1e, T1 + T2 vs T3 + T4, P < 0.01), and positive lymph node status (Fig. 1f, N0 vs. N1 + N2, P < 0.001). This evidence concerns the gene ADORA2A and neoplasm.