It has been reported that selective deletion of A2AR on myeloid cells caused potent tumor rejection which was associated with significant increases of MHC II and IL-12 expression in tumor-associated macrophages (TAMs) and reductions in IL-10 expression in TAMs, dendritic cells (DCs) and myeloid-derived suppressor cells (MDSCs) [51]. Here, ADORA2A is linked to neoplasm.