GFAP and Alzheimer disease: In comparison with WT mice, a higher number of GFAP-immunopositive astrocytes were observed in the hippocampus and cortex of mice with AD, but the number significantly decreased after AOE1 or Aβ15 treatment (t test; cortex, p = 0.02 for AOE1, p = 0.02 for Aβ15, n = 7; hippocampus, p < 0.001 for AOE1, p < 0.001 for Aβ15, n = 7) (Fig. 7a and c).