Inhibition of p110α by PIK-75 or A66 is sufficient to suppress GBM cell viability, migration and invasion, whereas inhibition of p110β by TGX-221 only blocks cell migration, and inhibition of p110δ by IC87114 or CAL-101 moderately impedes cell proliferation and migration [19, 23]. The gene discussed is PIK3CD; the disease is glioblastoma.