It also promotes tumor necrosis factor-related apoptosis inducing ligand (TRAIL)- and Bcl-2 inhibitor-induced apoptosis in GBM cells via elevated Noxa expression, sequestration of Mcl-1 by Noxa and release of pro-apoptotic protein Bim and Bak from Mcl-1 [37, 38]. This evidence concerns the gene PMAIP1 and glioblastoma.