IRF1 and Hypertension: Hcmv-miR-UL112-3p targets IRF-1 and MICB, which are two key molecules in immunological, inflammatory and anti-infective responses, and IRF-1 and MICB repression by hcmv-miR-UL112-3p may be a unifying mechanism that evades the host response in the pathogenesis of hypertension [18].