Consistent with the nutrient dependent upregulation of AMPK family protein, BRSK2 expression level is inversely related to microvessel density (MVD) and microvessel coverage fraction in pancreatic cancer (Supplementary Figure 2A and 2B; r= -0.349, p<0.001; r=-0.255, p<0.008). Here, BRSK2 is linked to pancreatic neoplasm.