To verify whether Gal-8 impacts upon the resistance to anoikis, we studied caspase-3 cleavage in all cell lines, and found that Gal-8 silencing promoted the cleavage of this caspase, further supporting the anti-apoptotic role of this lectin in PCa tumour cells (Figure 7b–7d). The gene discussed is CASP3; the disease is neoplasm.