We have recently showed a regulated pattern of expression of galectins along PCa progression, showing that Gal-1 is the most expressed member of this family and the only one that is progressively increased throughout the evolution of the disease, Gal-3 is decreased and turned off at advanced stages of the disease, and Gal-8 is highly expressed but does not show any regulation during PCa progression [11], making it a suitable candidate for targeting throughout the entire disease. The gene discussed is LGALS3; the disease is posterior cortical atrophy.