Since we have already demonstrated high oncogenic and metastatic properties of IGR-CaP1 cell line (IGR-CaP1) [20–21], and since PC3 cell line (PC3) is one of the most used models for PCa studies, we decided to use both in our further exploration of the role of Gal-8 in the PCa progression. Here, LGALS8 is linked to posterior cortical atrophy.