Even though the reasons why Gal-8 is solely expressed in the neoplastic prostate and its implications in prostate carcinogenesis still leave some interesting unanswered questions, we show here for the first time that controlling the expression of Gal-8 was enough to completely abolish metastasis development of a human PCa cell line with highly-expressed cancer stem cell markers. Here, LGALS8 is linked to posterior cortical atrophy.