As already shown for other galectins, namely Gals-1 and -3 in other human carcinomas [34–37], the present study suggests that Gal-8 may also induce cytoskeleton reorganization, with a profound impact on the promotion of homotypic aggregation and consequent protection against apoptosis induced by the loss of cell anchorage and E-Cadherin expression. This evidence concerns the gene LGALS8 and carcinoma.