BRCA2 and colorectal carcinoma: The mean number of mutations in BRCA2 was determined to be significantly higher in the MSI-H than the non-MSI-H CRCs (2.3 vs. 1.1, p<0.0001), suggesting that each CRC patient with MSI has a higher number of BRCA2 mutations than the patients in the non-MSI-H subtype (Figure 3C).