MSH2 and colorectal carcinoma: Unlike the previous reports (21, 25), our mutation analysis of the COSMIC dataset revealed a significantly higher EGFR mutation frequency in the MSH2/MLH1-mutant CRC (MSI-H) subtype (45.5% vs. 6.5% in non-MSI-H CRCs, p<0.0000001) (Figure 3B).