MLH1 and colorectal carcinoma: Among 101 MSH2/MLH1-mutant CRC (MSI-H) patients, 46 CRC patients had 88 (75 unique) somatic BRCA2 mutations including 9 frameshift/nonsense mutations (truncating the protein), 56 missense mutations, and 9 silent mutations along with one mutation in a splicing site (Table 1, Supplementary Figure 4).