As a consequence, 17 genes of the EMT-core upregulated genes were significantly upregulated in ESCC2 subtype, including well-known EMT makers such as ZEB1 and VIM (Figure 3B), while 22 genes of the EMT-core downregulated genes were significantly downregulated in ESCC2 subtype, including reported downregulated epithelial cell makers such as EPCAM, KRT17, PKP2 and PPL and some tumor suppressors such as KLK10 and SERPINB1 (Figure 3B). This evidence concerns the gene PKP2 and neoplasm.