ESCC4 tumors were enriched in cell markers CDK4, MCM4, DDX18, PHB, PA2G4, HSPD1 and HSPE1. This result represented the well characterized group of chromosomal instability (CIN) tumors for ESCC4 subtype. The gene discussed is HSPE1; the disease is cervical squamous intraepithelial neoplasia.