To determine whether cyclin D1 expression in HCC cells was reduced by M2-TAMs and whether this further inhibited apoptosis on oxaliplatin treatment, we first measured the changes in cyclin D1 and CDK4 expression in HCC cells co-cultured with M2-TAMs and treated with oxaliplatin for various times. The gene discussed is CCND1; the disease is hepatocellular carcinoma.