Conversely, silencing miR-196b-5p repressed the activity of JAK/STAT3 signaling, which further suppressed stem cell-like phenotypes and reversed the chemoresistance of CRC cells to 5-FU in vivo and in vitro, suggesting that targeting miR-196b-5p may be a potential anti-cancer therapeutic strategy against CRC. This evidence concerns the gene STAT3 and cancer.