The biological role and clinical significance of miR-196b-5p have been extensively studied and the majority of studies regarding miR-196b-5p converged on the hematologic malignancies, including mixed lineage leukaemia (MLL)-rearranged leukaemia, acute lymphoblastic leukemia, acute myeloid leukemia [40–43]. This evidence concerns the gene KMT2A and acute lymphoblastic leukemia.