As shown in Figure 7A and Supplementary Figure 6A–6C, miR-196b-5p expression level in CRC tissues was negatively associated with SOCS1 (r = −0.719, P < 0.05) and SOCS3 (r = −0.707, P < 0.05) protein expression, and positively correlated with nuclear pSTAT3 (r = 0.745, P < 0.05) protein expression. Here, SOCS1 is linked to colorectal carcinoma.