Mutations of MED12 were found in leiomyomas with a normal karyotype, with deletions or rearrangements of the long arm of chromosome 7 as sole anomaly, and with 6p21∼23 abnormalities leading to HMGA1 rearrangement/overexpression, and it was concluded that they precede the chromosomal aberrations [29]. This evidence concerns the gene HMGA1 and leiomyoma.