MYCN and neuroblastoma: Studies on Children's Oncology Group (COG) NB have focused on defining the risk groups for patient stratification and protocol assignment based on prognostic factors [3], including age at diagnosis [4], International Neuroblastoma Staging System (INSS) [5–7], International Neuroblastoma Pathology Classification (INPC), MYCN status, DNA index [8], 1p loss of heterogeneity (LOH) [9], and 11q LOH [10].