During consultation, patients were screened for the determination of anti-schistosome antibodies, by performing an enzyme immunoassay that uses purified S. mansoni antigen (NovaLisa Schistosoma mansoni IgG ELISA, NovaTec Immunodiagnostica GmbH), and total IgE; a single urine sample was collected and tested by using a POC assay to detect CCA for the diagnosis of S. mansoni infection (A&B Rapid Test Schistosomiasis CCA, Lucca Italy). The gene discussed is IGHE; the disease is schistosomiasis.