FPR1 and infection: To evaluate the influence of the second wave of neutrophil influx in lesion evolution and parasite load, we compared groups in which neutrophils were depleted with cyclophosphamide or their recruitment/activation was augmented with fMLP between days 16 and 22 p.i. In contrast to the results of modulation of neutrophil numbers early in the course of infection, a fMLP-mediated increase in neutrophils during the second wave of infiltration resulted in larger, more ulcerated, necrotic lesions (Fig 4A and 4B).