In the univariate model, diabetes, FTO rs3751812, and IL-6 rs1800796 were associated with neither OS nor PFS of breast cancer patients (all P values > 0.05) (S1 and S2 Figs), while HSPD1 rs2605039 was significantly associated with PFS (P = 0.031) (Fig 1A) but not OS (P = 0.061). The gene discussed is FTO; the disease is diabetes mellitus.