Such local imbalance of VWF and ADAMTS13 was recently demonstrated at sites of critical coronary stenosis in patients with ST-elevation myocardial infarction.[18] The pathogenic relevance of this imbalance is further supported by our results showing that the discrepancy between acute ischemic stroke patients and healthy volunteers is even more apparent when using the ratio of VWF:ADAMTS13 as compared to ADAMTS13 alone. Here, VWF is linked to coronary stenosis.