We therefore calculated the VWF:ADAMTS13 ratios in our study cohorts using previously determined VWF:Ag levels (Fig 1B).[8] Interestingly, stroke patients had a significantly higher VWF:ADAMTS13 ratio on day 0 (2.7 ± 1.9) compared with HV (1.1 ± 0.5; p<0.0001) and CCD patients (1.7 ± 0.7; p<0.0001). The gene discussed is RENBP; the disease is Stroke.