G6PD and G6PD deficiency: While the higher dose ultimately proved to be safe in 6 subjects with mild to moderate (WHO Class III) G6PD deficiency, prior to recovery at day 14, 3 of the 6 subjects experienced a >25% fractional drop in hemoglobin at day 7 compared to just 2/124, or 1.6% of G6PD-deficient volunteers given the lower 15mg dose in a recent study on the Thai-Myanmar border [26].