(Table 2.1) Four of which were in genes currently featured on newer comprehensive HBOC panels; two novel frameshift variants in ATM (c.2503_2507del and c.5697_5698insA) and two truncating variants in RAD51D (rs587781756 p.Q171* and rs387906843 p.R206*, as well as a pathogenic variant in a non-panel gene, FANCM (rs144567652 p.R1931*) previously found to be strongly associated with hereditary risk of breast cancer[5]. This evidence concerns the gene FANCM and breast cancer.