RAD52 mediates complementary ssDNA annealing and recruits RAD51 recombinase to promote recombination and homology directed DNA repair However, the RAD52 truncating variants that we observed in our sample have previously been found to lack an association with OVCA or breast cancer[35][36] but may modify the genetic penetrance of other variants in these pathways. This evidence concerns the gene RAD51 and breast cancer.