However, in agreement with our hypothesis of role as a possible modifier of penetrance, the BRCA2 K3326* truncation is found in The Cancer Genome Atlas (TCGA) in the analysis of the sequence of tumor DNAs database three times, each in OVCA patients who are all also carriers of pathogenic genetic variants; (TCGA-24-1562-01 with an NF1 frameshift, aTCGA-13-1512-01 and TCGA-23-1026-01 with BRCA1 frameshifts, (http://cancergenome.nih.gov/). This evidence concerns the gene BRCA1 and neoplasm.