For osteoprotegerin (OPG), mild moxibustion (MD 10.43 pg/ml, 95%CI 7.48 pg/ml to 13.38 pg/ml) [32] or heat-sensitive moxibustion (MD 3.16 pg/ml, 95%CI 0.81 pg/ml to 5.51 pg/ml) [36] had a better add-on benefit compared with anti-osteoporosis medicine alone. Here, TNFRSF11B is linked to osteoporosis.