By univariate regression analysis, old age, female sex, hypertension, diabetic retinopathy and nephropathy, high HbA1c SD, high triglyceride, low HDL-cholesterol, low eGFR, ACEI and/or ARB use, aspirin use, statin and/or fibrate use, and insulin use were associated with significantly greater risk of cardiovascular events. The gene discussed is INS; the disease is diabetic retinopathy.