Subgroup analyses showed that high HOTAIR expression was closely correlated with lymph node metastasis in estrogen-dependent carcinomas (OR = 3.87, 95% CI = 1.12–13.33, P = .03), digestive system carcinomas (OR = 2.92, 95% CI = 2.07–4.11, P < .001), and OSCCs (OR = 4.83, 95% CI = 1.65–14.17, P = .004), but not in respiratory system carcinomas (OR = 1.71, 95% CI = 0.49–6.05, P = .40). The gene discussed is HOTAIR; the disease is metastatic malignant neoplasm in the lymph nodes.