HOTAIR enhances hepatocellular cancer cell proliferation and tumorigenicity in vivo by suppressing miR-218, which acts as tumor suppressor in bladder cancer.[80,82] In gallbladder cancer, HOTAIR promotes cell proliferation and metastasis by inhibiting miR-130a expression.[83] The cross-regulation between HOTAIR and miRNAs in cancers reveals a novel strategy for using a combination of HOTAIR and miRNAs for tumor progression and prognostic markers. This evidence concerns the gene HOTAIR and gallbladder cancer.