Moreover, HOTAIR expression strongly related to lymph node metastasis in patients with preoperative treatment (OR = 7.65, 95% CI = 2.12–27.57, P = .002) and without preoperative treatment (OR = 2.99, 95% CI = 2.01–4.46, P < .001). This evidence concerns the gene HOTAIR and metastatic malignant neoplasm in the lymph nodes.