HOTAIR and gastric cancer: Upregulation of HOTAIR is found in cisplatin-resistant gastric cancer cells, and it promotes cell proliferation by inhibiting microRNA (miRNA)-126 expression and activating the PI3K/AKT/MRP1 pathway.[74] Furthermore, HOTAIR has been shown to enhance the resistance of ovarian cancer cells to cisplatin via the wnt/β-catenin pathway.[75] The involvement of HOTAIR in drug resistance further confirms its prognostic value.