No single etiologic factor fully accounts for the spectrum of abnormalities in PCOS.[4] The most obvious neuroendocrine feature in PCOS is increased luteinizing hormone (LH) pulsatility, with relatively low follicular stimulating hormone (FSH) secretion.[5] One of the common features of PCOS is insulin resistance, reported in 62% to 95% of women with PCOS.[6] Elevated androgen level, another common feature of PCOS, affects around 60% to 80% of women with PCOS and can produce clinical signs like hirsutism, acne, and alopecia.[7]. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.