PPARGC1A and diabetes mellitus: Another study suggested that the C allele of rs2946386 in the promoter region of the PPARGC1A gene was not associated with T2DM.[14] In the present study, susceptibility analysis on the UCP1 gene revealed that the genotypes and allele distribution of the 4 SNPs in the UCP1 gene (rs45539933, rs2270565, rs1494808 and rs1800592) were also not significantly different between the IFG+DM and NFPG groups, suggesting no association between these polymorphisms and IFG or T2DM.