It no longer requires the normal distributional assumption on data.[17,18] Therefore, we used data from a cross-sectional study in Henan province to establish the haplotypes of the PPARGC1A and UCP1 genes and then analyze the correlation and interaction between these genes by the KCCA method to explore their relationship with IFG or T2DM. The gene discussed is PPARGC1A; the disease is type 2 diabetes mellitus.