A quantitative proteomic analysis revealed that HD pathogenesis may be linked to changes in Htt interactions with stress granule-associated RNA-binding proteins (i.e., cytoplasmic activation- and proliferation-associated protein 1 (Caprin-1) and GTPase-activating protein Src homology 3 (SH3) domain-binding protein 1 (G3BP-1)) [91]. This evidence concerns the gene HTT and Huntington disease.