MYC and cancer: Because oncogenic MYC transcriptionally stimulates a number of DSB repair genes [127,128,129,130] and is responsible for the maintenance of cancer stemness [137,138], we propose that, under devastating genotoxic stress and/or during the maintenance of cancer stemness, oncogenic MYC protects the cancer-cell genome from DNA damage, thereby allowing advanced cancer (or cancer stem) cells to survive longer.