During obesity, fat depots also produce other molecules involved in angiogenesis, such as the Vascular Endothelial Growth Factor (VEGF) [76], or the Placental Growth Factor (PlGF) [77], which belong to the family of the Vascular Endothelial Growth Factors (VEGFs). The gene discussed is VEGFA; the disease is obesity due to melanocortin 4 receptor deficiency.