Accumulating evidence indicates that ephrins and Ephs affect bone homeostasis both in normal conditions and in a range of pathologic conditions such as osteoporosis and cancer‐induced bone disease.29 Although some studies have assessed through the regulation on ephrin/Eph signalling that LPS are involved,30, 31 they have largely evaluated the lung injury model30 or osteoblast‐osteoclast co‐culture systems.31 The regulation on ephrin/Eph signalling in human PDL with LPS stimulation has not been assessed. Here, EPHA1 is linked to osteoporosis.