Additionally, the small molecule cyclopamine, an steroidal alkaloid, and its semisynthetic analogue, IPI‐269609, have shown efficacy against pancreatic cancer metastasis through the inhibition of Hedgehog signaling, downregulation of Snail1, and upregulation of E‐cadherin in cells undergoing EMT (Katoh and Katoh, 2009). Here, SNAI1 is linked to familial pancreatic carcinoma.