The relocalization to the cytoplasm and/or nucleus of β‐catenin, an architectural membrane protein in adherens junctions, has been associated with CRC progression (reviewed in Schmalhofer et al., 2009) and similar relocalization of p120 catenin has been detected in breast tumors and carcinosarcomas (Sarrio et al., 2004, 2008). The gene discussed is CTNND1; the disease is colorectal carcinoma.