CDH2 and neoplasm: Thus, the main obstacle for the clinical application of CTC detection is that CTCs are presently isolated using microfluidic separation reliant on EpCAM, an epithelial marker (Harouaka et al., 2014) whose expression is completely lost when tumor cells begin to express key mesenchymal markers such as N‐cadherin and/or vimentin (Armstrong et al., 2011).