Although not directly addressing the metastatic potential, another transgenic breast cancer model based on the overexpression of Twist1 in the context of H‐Ras activation led to highly undifferentiated invasive tumors (Fig. 1A) with a claudin‐low phenotype (Morel et al., 2012) that exhibited intrinsic EMT features (Taube et al., 2010). The gene discussed is TWIST1; the disease is breast cancer.