HTT and amyotrophic lateral sclerosis: For instance, the intracellular Lewy bodies containing aggregated α-synuclein, the inclusions of aggregated huntingtin protein and the inclusions of copper–zinc superoxide dismutase (SOD1) mutants are histological hallmarks found in Parkinson's disease (PD), Huntington's disease and amyotrophic lateral sclerosis, respectively.