In contrast to a recent study where IL-2/Jes6-1 treatment of Ldlr−/−/Rag2−/− mice led to a substantial reduction of plasma VLDL-cholesterol levels26, our treatment of Apoe−/−/Rag2−/− mice with IL-2 was successful in reducing the effect of HFD on the progression of atherosclerosis, without any change in plasma lipid levels (Supplementary Fig. 3B). This evidence concerns the gene RAG2 and atherosclerosis.