In contrast to a recent study where IL-2/Jes6-1 treatment of Ldlr−/−/Rag2−/− mice led to a substantial reduction of plasma VLDL-cholesterol levels26, our treatment of Apoe−/−/Rag2−/− mice with IL-2 was successful in reducing the effect of HFD on the progression of atherosclerosis, without any change in plasma lipid levels (Supplementary Fig. 3B). The gene discussed is APOE; the disease is atherosclerosis.